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  • UK REACH - PFAS firefighting foams - Call for evidence

    ***This consultation has been extended to 24 June 2024 to allow more time for stakeholders to prepare a response.*** We are gathering information and evidence relating to firefighting foams which contain per- and polyfluoroalkyl substances (PFAS). The following video provides some background and describes the types of information we are looking for. Further background can be found below. In the first instance, we would like stakeholders to... More
    Closed 24 June 2024

  • UK REACH Testing Proposal 009

    Substance Name : Reaction product of propylidynetrimethanol, propoxylated, reaction products with ammonia and 2,2-Dimethyl-3-(4-morpholinyl)propanal CAS Number : 1379822-00-0 EC Number : 700-879-7 The hazard endpoints for which vertebrate testing was propose d Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) Parties concerned are invited to provide ... More
    Closed 2 May 2024

  • UK REACH Testing Proposal 008

    Substance Name : N-[3-({[2,2-dimethyl-3-(morpholin-4-yl)propylidene]amino}methyl)-3,5,5-trimethylcyclohexyl]-2,2-dimethyl-3-(morpholin-4-yl)propan-1-imine CAS Number : 1217271-02-7 EC Number : 700-584-3 The hazard endpoints for which vertebrate testing was propose d Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral Parties concerned are invited to ... More
    Closed 2 May 2024

  • UK REACH - RMOA for formaldehyde and formaldehyde releasers

    The UK REACH work programme for 2022/23 states that the Agency for UK REACH will initiate a Regulatory Management Options Analysis (RMOA) that examines exposure of the general public to formaldehyde from formaldehyde releasers in articles. RMOA is a process through which the Agency assess the potential risks posed by a substance (or group of substances), identifies areas where further information is needed to fill information gaps and recommends regulatory measures to... More
    Closed 25 June 2023

  • UK REACH Testing Proposal 007

    Substance Name : (R)-1-((4-amino-2-bromo-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol 4-methylbenzenesulfonate IUPAC Name : (R)-1-((4-amino-2-bromo-5-fluorophenyl)amino)-3-(benzyloxy)propan-2-ol 4-methylbenzenesulfonate CAS Number : 1294504-64-5 EC Number : 810-796-9 The hazard endpoint(s) for which vertebrate testing was propose d Genetic toxicity in vivo (OECD TG 474: Mammalian Erythrocyte Micronucleus... More
    Closed 11 May 2023

  • UK REACH – RMOA for the cyclic siloxanes D4, D5 and D6 – call for evidence

    The UK REACH work programme for 2022/23 states that the Agency for UK REACH will carry out an assessment to decide if it should recommend that the cyclic siloxanes octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6) are added to Annex 14 (the Authorisation List) of UK REACH. This assessment will take the form of a Regulatory Management Options Analysis (RMOA). RMOA is a process through which the Agency assess the... More
    Closed 1 May 2023

  • RMOA for bisphenols including the use of bisphenols in thermal paper and other uses

    The UK REACH work programme for 2022/23 states that the Agency for UK REACH will initiate a Regulatory Management Options Analysis (RMOA) that examines the use of bisphenols in thermal papers. Since 2 January 2020, a restriction has been in place which prevents the supply of thermal papers containing bisphenol A (BPA) in a concentration equal to or greater than 0.02 % by weight. Evidence gathered by the EU suggests that BPA may have been... More
    Closed 8 April 2023

  • UK REACH – Terphenyl, hydrogenated RMOA – Call for evidence

    The UK REACH work programme for 2022/23 states that the Agency for UK REACH will carry out an assessment to decide if it should recommend that terphenyl, hydrogenated is added to Annex 14 (the Authorisation List ) of UK REACH. This assessment will take the form of a Regulatory Management Options Analysis (RMOA). This call for evidence aims to gather information and evidence that will support the preparation of this RMOA. We are keen to obtain GB specific... More
    Closed 8 April 2023

  • UK REACH Testing Proposal 006

    Substance Name : di-''isononyl'' phthalate IUPAC Name : bis(7-methyloctyl) benzene-1,2-dicarboxylate CAS Number : 28553-12-0 EC Number : 249-079-5 The hazard endpoints for which vertebrate testing was propose d Pre-natal developmental toxicity study in a second species; rabbits (using OECD Test guideline 414) Parties concerned are invited to provide scientifically valid... More
    Closed 9 December 2022

  • UK REACH – Restriction Proposals 003 - Substances and groups of substances that pose a risk to human health if they are present in tattoo inks and permanent make-up (PMU)

    On 29 April 2021, the Health and Safety Executive (HSE) as the Agency for UK REACH received a request under Article 69(1) of UK REACH from the Defra Secretary of State, with the consent of the Scottish Government and the Welsh Government, to prepare an Annex 15 restriction dossier assessing the risks to humans from substances in tattoo ink and permanent make up (PMU). As of 4 January 2022, the European Union (EU) has restricted the presence of over 4000 potentially harmful substances in... More
    Closed 6 November 2022

  • UK REACH Testing Proposal 005

    Substance name : (E)-N-{6-[(E)-({2-[2-(heptan-3-yl)-1,3-oxazolidin-3-yl]ethoxy}(hydroxy)methylidene)amino]hexyl}{2-[2-(heptan-3-yl)-1,3-oxazolidin-3-yl]ethoxy}carboximidic acid CAS Number : 140921-24-0 EC Number : 925-259-5 The hazard endpoints for which vertebrate testing was propose d Repeated Dose 90-Day Oral Toxicity Study in Rodents (OECD 408) Pre-natal Developmental Toxicity Study in Rodents (OECD 414) ... More
    Closed 6 December 2021

  • UK REACH – restriction proposals 002 - Call for evidence: substances in tattoo inks and permanent make-up (PMU)

    We are gathering information and evidence to support the development of a UK REACH restriction dossier (report) on risks to human health arising from the use of certain pigments and other substances in tattoo ink and permanent make-up (PMU). UK REACH came into force at the end of the EU exit transition period (31st December 2020) and regulates the access of chemicals to the GB market. Under the Northern Ireland Protocol, EU REACH continues to regulate the access of chemicals to the... More
    Closed 2 November 2021

  • UK REACH Testing Proposal 004

    Substance name : 1-(4-(acetyloxy)-3-((acetyloxy)methyl)phenyl)ethenone CAS Number : 24085-06-1 EC Number : 921-042-4 The hazard endpoint for which vertebrate testing was proposed Genetic toxicity in vivo (using OECD Guideline 474: Mammalian Erythrocyte Micronucleus Test and OECD Guideline 489: In Vivo Mammalian Alkaline Comet Assay) Parties concerned are invited to provide scientifically valid information... More
    Closed 30 September 2021

  • UK REACH Testing Proposal 002

    Substance name : 2,2-dimethyl-3-oxopropyl dodecanoate CAS Number : 102985-93-3 EC Number : 468-880-2 The hazard endpoint for which vertebrate testing was proposed Long term toxicity to fish using OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test) Parties concerned are invited to provide scientifically valid information and studies that address the relevant substance and hazard... More
    Closed 30 September 2021

  • UK REACH Testing Proposal 001

    Substance name : 2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate CAS Number : 57583-35-4 EC Number : 260-829-0 The hazard endpoint for which vertebrate testing was proposed Genetic toxicity in vivo (comet assay in liver and duodenum combined with bone marrow micronucleus evaluation) Parties concerned are invited to provide scientifically valid information and... More
    Closed 30 September 2021

  • UK REACH Testing Proposal 003

    Substance name : hexyl salicylate CAS Number : 6259-76-3 EC Number : 228-408-6 The hazard endpoint for which vertebrate testing was proposed Sub-chronic toxicity in the rat (90-day): oral (using OECD Test Guideline 408) Deviation: an additional reproductive toxicity cohort of females will be included to cover the endpoints of a reproduction/developmental screening test according to OECD TG 421; males of the toxicity... More
    Closed 30 September 2021
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