UK REACH - Proposal for identification of a substance of very high concern (SVHC) for inclusion on the Candidate List – 2-(4-tert-butylbenzyl)propionaldehyde and its individual stereoisomers (Lysmeral) - Health and Safety Executive

Overview

Proposal to identify a substance of very high concern (SVHC) for inclusion on the Candidate List of UK REACH

HSE, as the Agency for UK REACH and with support from the Environment Agency, may propose the identification of substances of very high concern (SVHCs) for inclusion on the UK REACH Candidate List.

In accordance with Article 57 of UK REACH, substances with the following properties may be identified as SVHCs:

Substances meeting the criteria for classification as carcinogenic, mutagenic or toxic for reproduction (CMR) category 1A or 1B in accordance with the GB CLP regulation.
Substances that are persistent, bio-accumulative and toxic (PBT) in accordance with the criteria in Annex 13 of UK REACH.
Substances that are very persistent and very bio-accumulative (vPvB) in accordance with the criteria in Annex 13 of UK REACH.
Substances giving rise to an equivalent level of concern to substances meeting the above criteria. Such substances may have endocrine disrupting properties or there may be scientific evidence of probable serious effects to human health or the environment, although not meeting the criteria to be a CMR, PBT or vPvB. Such substances will be identified on a case-by-case basis

Before including substances on the Candidate List, HSE is required to prepare proposals in accordance with Annex 15 of UK REACH and make these publicly available on its website. Interested parties are invited to submit comments on these SVHC proposals within 6-weeks of the publication date.

If HSE does not receive any comments on an SVHC proposal, the substance will be added to the Candidate List. If comments are received, HSE will consider these comments and make a decision regarding inclusion of the substance on the Candidate List within 45 days of the end of the consultation.

Further information on the process for including SVHCs on the Candidate List is provided here UK REACH substances of very high concern (SVHCs)

The full list of substances HSE are consulting on at this time can be accessed via the ‘related’ section below.

How to submit comments

Comments on the following substance can be submitted by accessing the online survey below:

Substance name: 2-(4-tert-butylbenzyl)propionaldehyde and its individual stereoisomers (Lysmeral)

CAS Number: N/A

EC Number: N/A

SVHC-relevant intrinsic property: Toxic for reproduction (Article 57c)

The SVHC proposal on 2-(4-tert-butylbenzyl)propionaldehyde and its individual stereoisomers (Lysmeral) provides further information. This can be found in the ‘related documents’ section below.

The SVHC identification is based on the hazardous properties of a substance. SVHC proposals based on mandatory classification and labelling (MCL) included in the GB MCL list cannot be challenged in the SVHC identification process. Comments questioning the MCL will not be considered in this context.

Comments and additional information relating to how the substance is used, the volumes per use and the potential exposure and availability of alternatives can also be submitted. This information will not be used to confirm the SVHC identification but it may help to inform future actions, such as recommendations of priority substances for inclusion in the authorisation list of UK REACH.

Consultations close at 23:59 London time (BST) on 17 April 2026.

Related substances

You can submit comments on the other 14 substances included in this consultation by using this link, or you can return to the HSE Consultations Hub homepage to find all live consultations.

HSE’s Confidentiality and GDPR statements HSE’s Confidentiality and GDPR statements

Information provided in response to this consultation may be subject to publication or disclosure in accordance with the access to information regimes (these are primarily the Freedom of Information Act 2000 (FOIA), the General Data Protection Regulations (GDPR) and the Environmental Information Regulations 2004 (EIR)). Statutory Codes of Practice under the FOIA and EIR also deal with confidentiality obligations, among other things.

If you would like us to treat any of the information you provide as confidential, please make this clear in your response. Ideally, confidential information should be submitted using the functionality provided at the end of the process for attaching confidential documents. If we receive a request under FOIA or EIR for the information you have provided, we will take full account of your explanation, but we cannot give an assurance that confidentiality can be maintained in all circumstances.

An automatic confidentiality disclaimer generated by your IT system will be disregarded for these purposes. Requests for confidentiality should be made explicit within the body of the response.

HSE will process all personal data in accordance with the GDPR. This means that personal data will not normally be disclosed to third parties and any such disclosures will only be made in accordance with the Regulations.

Submit your comments

Online Survey

Audiences

Proposal for SVHC identification and inclusion of substances on the Candidate List of UK REACH

Interests

Registration, Evaluation, Authorisation & restriction of CHemicals (REACH)

UK REACH - Proposal for identification of a substance of very high concern (SVHC) for inclusion on the Candidate List – 2-(4-tert-butylbenzyl)propionaldehyde and its individual stereoisomers (Lysmeral)